Actividad antitumoral de los organismos marinos
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Resumen
El estudio de los productos naturales provenientes de los organismos marinos constituye un campo de investigación científica relativamente reciente, con amplias potencialidades teniendo en cuenta que los océanos cubren las tres cuartas partes de la superficie terrestre. Poriferos (esponjas) y Bryozoos, han sido los dos filos mas estudiados dado su vulnerabilidad, su cuerpo blando, su hábitat fijado a rocas o de movimiento lento y sus colores llamativos, por lo que son capaces de producir sustancias químicas, como método de autodefensa contra sus depredadores. Similar mecanismo defensivo exhiben las algas marinas, con la producción de metabolitos secundarios. En la presente comunicación se exponen los principales resultados obtenidos en el mundo y en Cuba hasta el presente en la búsqueda de sustancias con acción antitumoral a partir de organismos marinos.
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Valdés-Iglesias O., Pérez-GilR., & ColomY. (2020). Actividad antitumoral de los organismos marinos. Cub@: Medio Ambiente Y Desarrollo, 10(19). Recuperado a partir de https://cmad.ama.cu/index.php/cmad/article/view/148
Sección
Artículos
Citas
Bello, J. L. (1985a): Influencia del tratamiento con polisacáridos de origen marino sobre el prendimiento del tumor ascítico de Ehrlich. Rev. Cuba. Oncol. 1: 192.
Bello, J.L. (1985b): .Evidencias experimentales de la actividad inmuno-estimulante de un polisacárido de origen marino. Rev. Cuba. Oncol. 1: 200.
Biomundi (2001): Estado actual de las investigaciones y el desarrollo de fármacos de origen marino. IDICT Enero, 20 pág.
Blunt, J. W. ; Munro, M. H. G. (1999) MarinLit. vpc. Windows, Canterbury, Nueva Zelanda.
Cabrera Pedroso, M., E. Romeo, O. Valdés Iglesias (2003): Informe técnico “Análisis de la patentabilidad de los productos obtenidos de algas marinas para la industria farmacéutica y de cosméticos.” 3 Tomos, Oficina COMPITEC, OCPI.
Carbonnelle, D.; P. Pondaven; M. Morancais, G. Masse; S. Bosch, C. Jacquot, G. Briand; J. Robert, C. Roussakis (1999): Antitumor and anti-proliferative effects of an aqueous extract from the marine diatom Haslea ostrearia (Simonsen) against solid tumors: lung carcinoma (NSCLC-N6), kidney carcinoma (E39) and melanoma (M96) cell lines. Anticancer Res. Enero-Feb; 19 (1A):621-4.
Elloali, M., C. Boisson-Vidal, P. Durand, J. Jozefonvicz (1993): Antitumor activity of low molecular weight fucans extracted from brown seaweed Ascophylum nodosum. Anticancer Res. 13 (6A): 2011- 9.
Fernández, L.E. Valiente, O. Mainardi V., Bello, J.L Velez H. Y Rosado A. (1989): Isolation and characterisation of antitumor agar type polysaccharides of Gracilaria dominguesis. Carboh. Research 2 (4): 80-87.
Guan, Y., R. Sakai, K.L.Rinehart, A.H. Wang (1993): Molecular and crystal structures of ecteinascidins: potent antitumor compound from the Caribbean tunicate Ecteinascidin turbinata J. of Biomol. Struct. Dyn. 10: 793:818.
Harada, H., T. Noro, Y. Kamey (1997): “Selective antitumor activity from marine algae from Japan coasts”. Biol. Pharm. Bull. 20 (5): 541-6.
Hay, M. E. (1992): “The role of seaweed chemical defences in the evolution of feeding specialization and the mediation of complex interactions” en Ecological roles of marine naturals products” (V. J. Paul Ed.) Cosmotock Pub. Assoc. (93-108).
Hay, M.E. y W. Fenical (1992): “Chemical mediation of seaweed. Herbivore interactions”, Plant Animal Interactions in Marine Bentos (D.M. John) Systematic Ass. Special, Vol. No 36 pp. 319-333.
Higa, T. (1983): Chemical and Biological Perspectives. Marine Natural Products. Ed. Sheuer Vol. IV. Cap. 3. Academic Press, New York, pag. 93.
Jaspars, M. (1998): Testing the water Chemistry and Industry, 18 Jan, 51-55
Kashiwagi, M.; J.S. Miynderse, R.E. Moore, T.R. Norton (1980): Antineoplastic of Pacific Basin Marine Algae. Journal of Pharmaceutical Sciences, 69 (6), 735-738.
Khoulam, M., X. Ou, G Kalemkerian (1996): “Dolastatin 10 inhibits growth of small cell lung cancer”. Proc. Annual Meeting Am. Assoc. Cancer Research 37: A.2708.
Lage, A. Conceptos de la Quimioterapia Experimental. Actualidad en Oncología 2:3, 1980.
Lenhinger, A.I., D. Nelson, M. Cox (2006): “Principles of Biochemistry”, IV Edition, Worth Publisher, Canada, 1013 pág.
Long BH, Carboni JM, Wasserman AJ, Cornell LA, Casazza AM, Jensen PR, Lindel T, Fenical W, Fairchild CR. (1998): Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res. Mar 15: 58(6):1111-5.
Madden T.; T. H. Tran; D.Beck; R. Huie, R.A. Newman, L. Pusztai, J.J. Wright, J.L. Abbruzzese (2000): Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res , Apr. 6(4):1293-301.
Mayer, A. y K.R. Gustafson (2003): Marine Pharmacology in 2000: Antitumor and cytotoxic compounds. Int. J. Cancer: 105, 291-299.
Mayer, A. y M. T. Hamann (2004): Marine Pharmacology in 2000: Marine Compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis and antiviral activities; affecting the Cardiovascular, Immune and Nervous Systems and other miscelaneous mechanism of action. Mar. Biotechnology 6, 37-52.
Mayer, A. y M. T. Hamann (2005): Marine pharmacology in 2001–2002: Marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action Review Comparative Biochemistry and Physiology, Part C 140 (2005) 265 – 286.
Neushul, M. (1990): Antiviral carbohydrates from marine red algae. Hidrobiología 204/205; 99-104
Pec MK, Moser-Thier K, Fernandez JJ, Souto ML, Kubista E (1999): Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines.` Int J Oncol , Apr;14 (4):739-43
Pérez, R. M. (1985): Obtención de un sesquiterpeno con actividad tumoral de la esponja Smenospongia aurea de las costas cubanas. Rev. Cuba. Oncol. 1: 184.
Quanbin, Z. Pengzhan, Y. Zhien, L., Hong, Z.,Zunhong, X. y Pengcheng, L. (2003): Antioxidant activities of sulphated polysaccharides fractions from P. haitiensis. J. of Applied Phycology 15, 305-310.
Retz de Carvalho, L. y N.F.Roque, (2000): Fenóis halogenados e/ou sulfatados de macrolagas marinhas. Química Nova Vol. 23, No. 6, 757-764.
Rinehart, K.L. (2000): “Antitumor compounds from tunicates”. Med. Res.Rev.; 20(1): 1-27.
Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P., Roussakis C. (1996): Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Research, 10 (1).
Ross, D. W. (ed) (1998): “Molecular biology and their applications in the cancer treatment and diagnosis”. Introduction to oncogenes and molecular Cancer Medicine. Wiston-Salem, NC USA, 168 pp, 47 fig.
Sheu JH, Wang GH, Sung PJ, Duh CY (1999): New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides. J Nat Prod Feb. ;62 (2):224-7
Ungheri et al, (1994): Synergistic composition comprising a FGF and a sulphated polysaccharide for use as antiviral agent Patent USP 5,288,704
Valiente, O. Fernández, L.E., Pérez, R. (1991a): Estudio de la actividad biológica del coralán. 1 Actividad antitumoral directa. Rev. Cubana de Oncología , 7, (1), 30-33.
Valiente, O. Fernández, L.E., Pérez, R (1991b): Estudio de la actividad biológica del coralán. 2 Actividad antitumoral indirecta. Rev. Cubana de Oncología, 7, (2), 34-37.
Valoti, G., M.I. Nicoletti, A. Pellegrino, J. Jimeno, H. Hendriks, M. D Incalci, G. Faircloth, R. Giavanzzi (1998) Ecteinascidin- 743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts. Clinical Cancer Research, Vol 4, 1977-1983.
Bello, J.L. (1985b): .Evidencias experimentales de la actividad inmuno-estimulante de un polisacárido de origen marino. Rev. Cuba. Oncol. 1: 200.
Biomundi (2001): Estado actual de las investigaciones y el desarrollo de fármacos de origen marino. IDICT Enero, 20 pág.
Blunt, J. W. ; Munro, M. H. G. (1999) MarinLit. vpc. Windows, Canterbury, Nueva Zelanda.
Cabrera Pedroso, M., E. Romeo, O. Valdés Iglesias (2003): Informe técnico “Análisis de la patentabilidad de los productos obtenidos de algas marinas para la industria farmacéutica y de cosméticos.” 3 Tomos, Oficina COMPITEC, OCPI.
Carbonnelle, D.; P. Pondaven; M. Morancais, G. Masse; S. Bosch, C. Jacquot, G. Briand; J. Robert, C. Roussakis (1999): Antitumor and anti-proliferative effects of an aqueous extract from the marine diatom Haslea ostrearia (Simonsen) against solid tumors: lung carcinoma (NSCLC-N6), kidney carcinoma (E39) and melanoma (M96) cell lines. Anticancer Res. Enero-Feb; 19 (1A):621-4.
Elloali, M., C. Boisson-Vidal, P. Durand, J. Jozefonvicz (1993): Antitumor activity of low molecular weight fucans extracted from brown seaweed Ascophylum nodosum. Anticancer Res. 13 (6A): 2011- 9.
Fernández, L.E. Valiente, O. Mainardi V., Bello, J.L Velez H. Y Rosado A. (1989): Isolation and characterisation of antitumor agar type polysaccharides of Gracilaria dominguesis. Carboh. Research 2 (4): 80-87.
Guan, Y., R. Sakai, K.L.Rinehart, A.H. Wang (1993): Molecular and crystal structures of ecteinascidins: potent antitumor compound from the Caribbean tunicate Ecteinascidin turbinata J. of Biomol. Struct. Dyn. 10: 793:818.
Harada, H., T. Noro, Y. Kamey (1997): “Selective antitumor activity from marine algae from Japan coasts”. Biol. Pharm. Bull. 20 (5): 541-6.
Hay, M. E. (1992): “The role of seaweed chemical defences in the evolution of feeding specialization and the mediation of complex interactions” en Ecological roles of marine naturals products” (V. J. Paul Ed.) Cosmotock Pub. Assoc. (93-108).
Hay, M.E. y W. Fenical (1992): “Chemical mediation of seaweed. Herbivore interactions”, Plant Animal Interactions in Marine Bentos (D.M. John) Systematic Ass. Special, Vol. No 36 pp. 319-333.
Higa, T. (1983): Chemical and Biological Perspectives. Marine Natural Products. Ed. Sheuer Vol. IV. Cap. 3. Academic Press, New York, pag. 93.
Jaspars, M. (1998): Testing the water Chemistry and Industry, 18 Jan, 51-55
Kashiwagi, M.; J.S. Miynderse, R.E. Moore, T.R. Norton (1980): Antineoplastic of Pacific Basin Marine Algae. Journal of Pharmaceutical Sciences, 69 (6), 735-738.
Khoulam, M., X. Ou, G Kalemkerian (1996): “Dolastatin 10 inhibits growth of small cell lung cancer”. Proc. Annual Meeting Am. Assoc. Cancer Research 37: A.2708.
Lage, A. Conceptos de la Quimioterapia Experimental. Actualidad en Oncología 2:3, 1980.
Lenhinger, A.I., D. Nelson, M. Cox (2006): “Principles of Biochemistry”, IV Edition, Worth Publisher, Canada, 1013 pág.
Long BH, Carboni JM, Wasserman AJ, Cornell LA, Casazza AM, Jensen PR, Lindel T, Fenical W, Fairchild CR. (1998): Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res. Mar 15: 58(6):1111-5.
Madden T.; T. H. Tran; D.Beck; R. Huie, R.A. Newman, L. Pusztai, J.J. Wright, J.L. Abbruzzese (2000): Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res , Apr. 6(4):1293-301.
Mayer, A. y K.R. Gustafson (2003): Marine Pharmacology in 2000: Antitumor and cytotoxic compounds. Int. J. Cancer: 105, 291-299.
Mayer, A. y M. T. Hamann (2004): Marine Pharmacology in 2000: Marine Compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis and antiviral activities; affecting the Cardiovascular, Immune and Nervous Systems and other miscelaneous mechanism of action. Mar. Biotechnology 6, 37-52.
Mayer, A. y M. T. Hamann (2005): Marine pharmacology in 2001–2002: Marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action Review Comparative Biochemistry and Physiology, Part C 140 (2005) 265 – 286.
Neushul, M. (1990): Antiviral carbohydrates from marine red algae. Hidrobiología 204/205; 99-104
Pec MK, Moser-Thier K, Fernandez JJ, Souto ML, Kubista E (1999): Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines.` Int J Oncol , Apr;14 (4):739-43
Pérez, R. M. (1985): Obtención de un sesquiterpeno con actividad tumoral de la esponja Smenospongia aurea de las costas cubanas. Rev. Cuba. Oncol. 1: 184.
Quanbin, Z. Pengzhan, Y. Zhien, L., Hong, Z.,Zunhong, X. y Pengcheng, L. (2003): Antioxidant activities of sulphated polysaccharides fractions from P. haitiensis. J. of Applied Phycology 15, 305-310.
Retz de Carvalho, L. y N.F.Roque, (2000): Fenóis halogenados e/ou sulfatados de macrolagas marinhas. Química Nova Vol. 23, No. 6, 757-764.
Rinehart, K.L. (2000): “Antitumor compounds from tunicates”. Med. Res.Rev.; 20(1): 1-27.
Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P., Roussakis C. (1996): Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Research, 10 (1).
Ross, D. W. (ed) (1998): “Molecular biology and their applications in the cancer treatment and diagnosis”. Introduction to oncogenes and molecular Cancer Medicine. Wiston-Salem, NC USA, 168 pp, 47 fig.
Sheu JH, Wang GH, Sung PJ, Duh CY (1999): New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides. J Nat Prod Feb. ;62 (2):224-7
Ungheri et al, (1994): Synergistic composition comprising a FGF and a sulphated polysaccharide for use as antiviral agent Patent USP 5,288,704
Valiente, O. Fernández, L.E., Pérez, R. (1991a): Estudio de la actividad biológica del coralán. 1 Actividad antitumoral directa. Rev. Cubana de Oncología , 7, (1), 30-33.
Valiente, O. Fernández, L.E., Pérez, R (1991b): Estudio de la actividad biológica del coralán. 2 Actividad antitumoral indirecta. Rev. Cubana de Oncología, 7, (2), 34-37.
Valoti, G., M.I. Nicoletti, A. Pellegrino, J. Jimeno, H. Hendriks, M. D Incalci, G. Faircloth, R. Giavanzzi (1998) Ecteinascidin- 743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts. Clinical Cancer Research, Vol 4, 1977-1983.