Antioxidants of Marine origin
Main Article Content
Abstract
Free radicals are defined as molecules containing one or more unpaired electrons in atomic or molecular orbital that give then, a considerable degree of reactivity. At high concentrations, reactive oxygen species (ROS) can be important mediators of damage to cell structure. However, this ROS are metabolized by antioxidants defenses, some synthesized in vivo and other diet-derived. Oxidative stress can be defined as the imbalance between biochemical processes leading to the production of reactive species and those responsible for their removing. Research over the past few decades has revealed the widespread involvement of oxidative stress in a number of disease states. In this regard, natural extracts rich in flavonoids have been recognized not only by theirs antioxidants properties but also by many other biological activities associated to oxidative stress. Thus, the sea has proven to be a very rich source of compounds with antitumor, anti-inflammatory as well as antioxidant effectss.
Article Details
How to Cite
Morales AguileraR. A., Fernández PérezM. D., & Menéndez Soto del ValleR. (2020). Antioxidants of Marine origin . Cub@: Medio Ambiente Y Desarrollo, 10(19). Retrieved from https://cmad.ama.cu/index.php/cmad/article/view/147
Section
Original Article
References
Boers, F., Lemiere, G., Lepoivre, J. A., De Groot, A., Dommisse, R., De Bruyne, T. 1998. Synthesis and antiviral activity of 7-O-(omega-substituted)-alkyl- 3-O-methylquercetin derivatives. Pharmazie 53 (8): 512–517.
Burritt, D., Rkindale, J., Hurd, C. L. 2002. Antioxidant metabolism in the intertidal red seaweed Stictosiphonia arbuscula following desiccation. Planta 215 (5): 829-838.
Chewa, Y. L., Lima, Y. Y., Omara M., Khoob, K. S. 2008. Antioxidant activity of three edible seaweeds from two areas in South East Asia. LWT 41: 1067–1072.
De, S., Adhikari, S., Tilak-Jain, J., Menon, V. P., Devasagayam, T. P. 2008. Antioxidant activity of an aminothiazole compound: possible mechanisms. Chem Biol Interact. Jun 17 173 (3): 215-23.
Echavarría, B., Franco, A., Martínez, A. 2009. Evaluación de la actividad antioxidante y determinación del contenido de compuestos fenólicos en extractos de macroalgas del caribe colombiano. Vitae 16 (1): 126-131.
Elejalde Guerra, J. I. 2001. Estrés oxidativo, enfermedades y tratamientos antioxidantes. An. Med. Interna (Madrid) 18 (6): 326-335.
Fallarero A, Loikkanen J. J., Männistö P. T., Castañeda O., Vidal A. 2003. Effects of aqueous extracts of Halimeda incrassata (Ellis) Lamouroux and Bryothamnion triquetrum (S.G.Gmelim) Howe on hydrogen peroxide and methyl mercury-induced oxidative stress in GT1-7 mouse hypothalamic immortalized cells. Phytomedicine 10: 39–47.
Fallarero, A., Peltoketo, J., Loikkanen, P., Tammela, A., Vidal, P., Vuorela. 2006. Effects of the aqueous extract of Bryothamnion triquetrum on chemical hypoxia and aglycemia-induced damage in GT1-7 mouse hypothalamic immortalized cells. Phytomedicine 13: 240–245.
Fernández, M. D., Hernández, I., Aneiros, A., Tello, J. 2007. Actividad antioxidante de extractos de algas. http://hdl.handle.net/1834/2604.
Ferry, D. R., Smith, A., Malkhandi, J., Fyfe, D. W., deTakats, P. G., Anderson, D. et al. 1996. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 2 (4): 659– 668.
Goudable, J., Favier, A. 1997. Oxidative free radicals and antioxidants. Nutrición Clinique et Metabolisme 11 (2): 115.
Halliwell, B. 2006. Oxidative stress and neurodegeneration: Where are we now? Journal of Neurochemistry 97: 1634–1658.
Halliwell, B. y Gutteridge, J. M. C. 1999. Free radicals in biology and medicine (3rd ed.). Oxford University Press.
Hertog, M. G., Hollman, P. C., Katan, M. B., Kromhout, D. 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer 20 (1): 21–29.
Honga, J. T., Ryua, S. R., Kima, H. J., Leea, J. K., Lee, S. H. 2001. Protective effect of green tea extract on ischemia/ reperfusion-induced brain injury in Mongolian gerbils. Brain Research 888: 11–18.
Kahkonen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J. P., Pihlaja, K., Kujala, T. S., Heinonen, M. 1999. Antioxidant activity of plant extracts containing phenolic compounds. J. Agric. Food Chem., Washington 47: 3954-3962.
Kim, H. P., Mani, I., Iversen, L., Ziboh, V. A. 1998. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea pigs. Prostaglandins Leukotrienes Essen. Fatty Acids 58 (1): 17–24.
Kornprobst, J.M., Sallenave, C. Barnathan, G. 1998. Sulfated compounds from marine organisms. Comp Biochem Physiol. 119 (1): 1-51.
Kumar SC., Ganesan OP., Bhaskar N. 2008. In vitro antioxidant activities of three selected brown seaweeds of India. Food Chemistry 107: 707–713.
Le Tutour, B., Benslimane, F., Gouleau, M. P., Gouygou, J. P., Saldan, B., Quemeneur, F. 1998. Antioxidant and prooxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum. J.Appl.Phycol.10: 121–129.
Linares, A. F, Loikanen, J, Jorge, M. F, Soria, R. B, Novoa, A. V. 2004. Antiioxidant and neuroportective activity of the extract from the seaweed Halimeda incresata against in vitro and in vivo toxicity induced by merthylmercury. Vet. Hum. Toxicol. 46: 1-5.
Nakai, M., Kageyama, N., Nakahara, K., Miki, W. 2006. Phlorotannins as Radical Scavengers from the Extract of Sargassum ringgoldianum. Marine Biotech. 8: 409-414.
McInnes, A. G., Ragan, M. A., Smith, D. G., Walter, J. A. 1985. The high molecular weight polyphloroglucinols of the marine brown alga Fucus vesiculosus L. 1H and 13C nuclear magnetic resonance spectroscopy. Can. J. Chem. 63: 304–313.
Nagai, T., Yukimoto, T. 2003. Preparation and functional properties of beberages made from sea algae. Food Chem. 81: 327-332.
Núñez, R., Garateix, A., Laguna, A., Fernández, M.D., Ortiz, E., Llanio, M., Valdés, O., Rodríguez, A., Menéndez, R. 2006. Caribbean marine biodiversity as a source of new compounds of biomedical interest and others industrial applications. Pharmacologyonline 3: 111-119.
Qi, H., Zhang, Q., Zhao T., R. Chen, Zhang H., Niu, X., Li Z. 2005. Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro. International Journal of Biological Macromolecules 37: 195–199.
Raghavendra, B., Rao, H., Sathivel, A., Devaki, T. 2004. Antihepatotoxcic nature of Ulva reticulata on acetaminophen induced heoatoxicity in experimental rats. J. Med. Food. 7, 495-497.
Rao, H., Raghavendran, B., Sathivel, A., Devaki, T. 2005. Protective effect of Sargassum polycystum (brown alga) against acetaminophen-induced lipid peroxidation in rats. Phytother Res. 19 (2):113-5.
Regalado, E. L., Rodríguez, M., Menéndez, E. L., Concepción, A., Nogueiras, C., Laguna, A. 2009. Repairs of UVB-Damages-Skin by the antioxidant sulphated flavone glicosyde Thalassiolin B isolated from the marine plant Thalassia testudinum Bank ex Konig. Mar Biotechnol (NY) 11(1): 74-80.
Rupérez, P., Ahrazem, O., Lea, J. A. 2002. Potential Antioxidant Capacity of Sulfated olysaccharides from the Edible Marine Brown Seaweed Fucus vesiculosus. J. Agfric. Food. Chem. 50 (4): 840–845.
Valdés, O., Hernádez, Y., Fernández, M. D., Hernández, I., Rodríguez, M., Cano, M., Laguna, A., Díaz, C., Cabrera, B. 2008. Actividad antioxidante de algas y plantas marinas de la plataforma insular cubana. http://hdl.handle.net/1834/282.
Vidal, A., Motidome, M., Mancini-Filho, J., Fallarero, A., Midori, M., Brandao, L. M., Lapa, A. J. 2001. Actividad antioxidante y ácidos fenólicos del alga marina Bryothamnion triquetrum (SG Gmelim) Howe. Brazilian J Pharm Sci. 37 (3): 373-382.
Vidal, A, Silva de Andrade-Wartha, E. R., de Oliveira e Silva, A. M., Pavan, R., Lima, A., Fallarero, A., Batista, A. E., Mancini-Filho, J. 2009. Actividad antioxidante y polifenoles de las algas marinas Halimeda opuntia y Halimeda monile. Ars Pharm. 50 (1): 24-31.
Wätjen, W., Putz, A., Chovolou, Y., Kampkötter, A., Totzke, F., Kubbutat, M. H., Proksch, P., Konuklugil, B. 2009. Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kappaB signalling in H4IIE cells. J Pharm Pharmacol. Jul 61 (7): 919-24.
Wei, Y., Li, Z., Hu, Y., Xu, Z. 2003. Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum. Journal of Applied Phycology 15: 507–511.
Wong, C. K, Ooi, V. C. E, Ang, Q. P. O. 2004. Hepatoprotective effect of seaweeds’ methanol extract against carbon tetrachloride-induced poisoning in rats. Hydrobiologia 512: 267–270.
Yan, X., Chuda, Y., Suzuki, M., Nagata, T. 1999. Fucoxanthin as the major antioxidant in Hijikia fusiformis, common edible seaweed. Biosci. Biotechnol. Biochem. 63 (3): 605-607.
Yuan, Y. V., Walsh, N. A. 2006. Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds. Food Chem. Toxicol. 44 (7): 1144-1150.
Burritt, D., Rkindale, J., Hurd, C. L. 2002. Antioxidant metabolism in the intertidal red seaweed Stictosiphonia arbuscula following desiccation. Planta 215 (5): 829-838.
Chewa, Y. L., Lima, Y. Y., Omara M., Khoob, K. S. 2008. Antioxidant activity of three edible seaweeds from two areas in South East Asia. LWT 41: 1067–1072.
De, S., Adhikari, S., Tilak-Jain, J., Menon, V. P., Devasagayam, T. P. 2008. Antioxidant activity of an aminothiazole compound: possible mechanisms. Chem Biol Interact. Jun 17 173 (3): 215-23.
Echavarría, B., Franco, A., Martínez, A. 2009. Evaluación de la actividad antioxidante y determinación del contenido de compuestos fenólicos en extractos de macroalgas del caribe colombiano. Vitae 16 (1): 126-131.
Elejalde Guerra, J. I. 2001. Estrés oxidativo, enfermedades y tratamientos antioxidantes. An. Med. Interna (Madrid) 18 (6): 326-335.
Fallarero A, Loikkanen J. J., Männistö P. T., Castañeda O., Vidal A. 2003. Effects of aqueous extracts of Halimeda incrassata (Ellis) Lamouroux and Bryothamnion triquetrum (S.G.Gmelim) Howe on hydrogen peroxide and methyl mercury-induced oxidative stress in GT1-7 mouse hypothalamic immortalized cells. Phytomedicine 10: 39–47.
Fallarero, A., Peltoketo, J., Loikkanen, P., Tammela, A., Vidal, P., Vuorela. 2006. Effects of the aqueous extract of Bryothamnion triquetrum on chemical hypoxia and aglycemia-induced damage in GT1-7 mouse hypothalamic immortalized cells. Phytomedicine 13: 240–245.
Fernández, M. D., Hernández, I., Aneiros, A., Tello, J. 2007. Actividad antioxidante de extractos de algas. http://hdl.handle.net/1834/2604.
Ferry, D. R., Smith, A., Malkhandi, J., Fyfe, D. W., deTakats, P. G., Anderson, D. et al. 1996. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 2 (4): 659– 668.
Goudable, J., Favier, A. 1997. Oxidative free radicals and antioxidants. Nutrición Clinique et Metabolisme 11 (2): 115.
Halliwell, B. 2006. Oxidative stress and neurodegeneration: Where are we now? Journal of Neurochemistry 97: 1634–1658.
Halliwell, B. y Gutteridge, J. M. C. 1999. Free radicals in biology and medicine (3rd ed.). Oxford University Press.
Hertog, M. G., Hollman, P. C., Katan, M. B., Kromhout, D. 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer 20 (1): 21–29.
Honga, J. T., Ryua, S. R., Kima, H. J., Leea, J. K., Lee, S. H. 2001. Protective effect of green tea extract on ischemia/ reperfusion-induced brain injury in Mongolian gerbils. Brain Research 888: 11–18.
Kahkonen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J. P., Pihlaja, K., Kujala, T. S., Heinonen, M. 1999. Antioxidant activity of plant extracts containing phenolic compounds. J. Agric. Food Chem., Washington 47: 3954-3962.
Kim, H. P., Mani, I., Iversen, L., Ziboh, V. A. 1998. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea pigs. Prostaglandins Leukotrienes Essen. Fatty Acids 58 (1): 17–24.
Kornprobst, J.M., Sallenave, C. Barnathan, G. 1998. Sulfated compounds from marine organisms. Comp Biochem Physiol. 119 (1): 1-51.
Kumar SC., Ganesan OP., Bhaskar N. 2008. In vitro antioxidant activities of three selected brown seaweeds of India. Food Chemistry 107: 707–713.
Le Tutour, B., Benslimane, F., Gouleau, M. P., Gouygou, J. P., Saldan, B., Quemeneur, F. 1998. Antioxidant and prooxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum. J.Appl.Phycol.10: 121–129.
Linares, A. F, Loikanen, J, Jorge, M. F, Soria, R. B, Novoa, A. V. 2004. Antiioxidant and neuroportective activity of the extract from the seaweed Halimeda incresata against in vitro and in vivo toxicity induced by merthylmercury. Vet. Hum. Toxicol. 46: 1-5.
Nakai, M., Kageyama, N., Nakahara, K., Miki, W. 2006. Phlorotannins as Radical Scavengers from the Extract of Sargassum ringgoldianum. Marine Biotech. 8: 409-414.
McInnes, A. G., Ragan, M. A., Smith, D. G., Walter, J. A. 1985. The high molecular weight polyphloroglucinols of the marine brown alga Fucus vesiculosus L. 1H and 13C nuclear magnetic resonance spectroscopy. Can. J. Chem. 63: 304–313.
Nagai, T., Yukimoto, T. 2003. Preparation and functional properties of beberages made from sea algae. Food Chem. 81: 327-332.
Núñez, R., Garateix, A., Laguna, A., Fernández, M.D., Ortiz, E., Llanio, M., Valdés, O., Rodríguez, A., Menéndez, R. 2006. Caribbean marine biodiversity as a source of new compounds of biomedical interest and others industrial applications. Pharmacologyonline 3: 111-119.
Qi, H., Zhang, Q., Zhao T., R. Chen, Zhang H., Niu, X., Li Z. 2005. Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro. International Journal of Biological Macromolecules 37: 195–199.
Raghavendra, B., Rao, H., Sathivel, A., Devaki, T. 2004. Antihepatotoxcic nature of Ulva reticulata on acetaminophen induced heoatoxicity in experimental rats. J. Med. Food. 7, 495-497.
Rao, H., Raghavendran, B., Sathivel, A., Devaki, T. 2005. Protective effect of Sargassum polycystum (brown alga) against acetaminophen-induced lipid peroxidation in rats. Phytother Res. 19 (2):113-5.
Regalado, E. L., Rodríguez, M., Menéndez, E. L., Concepción, A., Nogueiras, C., Laguna, A. 2009. Repairs of UVB-Damages-Skin by the antioxidant sulphated flavone glicosyde Thalassiolin B isolated from the marine plant Thalassia testudinum Bank ex Konig. Mar Biotechnol (NY) 11(1): 74-80.
Rupérez, P., Ahrazem, O., Lea, J. A. 2002. Potential Antioxidant Capacity of Sulfated olysaccharides from the Edible Marine Brown Seaweed Fucus vesiculosus. J. Agfric. Food. Chem. 50 (4): 840–845.
Valdés, O., Hernádez, Y., Fernández, M. D., Hernández, I., Rodríguez, M., Cano, M., Laguna, A., Díaz, C., Cabrera, B. 2008. Actividad antioxidante de algas y plantas marinas de la plataforma insular cubana. http://hdl.handle.net/1834/282.
Vidal, A., Motidome, M., Mancini-Filho, J., Fallarero, A., Midori, M., Brandao, L. M., Lapa, A. J. 2001. Actividad antioxidante y ácidos fenólicos del alga marina Bryothamnion triquetrum (SG Gmelim) Howe. Brazilian J Pharm Sci. 37 (3): 373-382.
Vidal, A, Silva de Andrade-Wartha, E. R., de Oliveira e Silva, A. M., Pavan, R., Lima, A., Fallarero, A., Batista, A. E., Mancini-Filho, J. 2009. Actividad antioxidante y polifenoles de las algas marinas Halimeda opuntia y Halimeda monile. Ars Pharm. 50 (1): 24-31.
Wätjen, W., Putz, A., Chovolou, Y., Kampkötter, A., Totzke, F., Kubbutat, M. H., Proksch, P., Konuklugil, B. 2009. Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kappaB signalling in H4IIE cells. J Pharm Pharmacol. Jul 61 (7): 919-24.
Wei, Y., Li, Z., Hu, Y., Xu, Z. 2003. Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum. Journal of Applied Phycology 15: 507–511.
Wong, C. K, Ooi, V. C. E, Ang, Q. P. O. 2004. Hepatoprotective effect of seaweeds’ methanol extract against carbon tetrachloride-induced poisoning in rats. Hydrobiologia 512: 267–270.
Yan, X., Chuda, Y., Suzuki, M., Nagata, T. 1999. Fucoxanthin as the major antioxidant in Hijikia fusiformis, common edible seaweed. Biosci. Biotechnol. Biochem. 63 (3): 605-607.
Yuan, Y. V., Walsh, N. A. 2006. Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds. Food Chem. Toxicol. 44 (7): 1144-1150.